ABOUT ―
Study "in vivo" on the effects of PEMF induced by the BIO-STIM® System on various parameters of the immune system of three (3) normal voluntary human subjects. (Report T06.198-01.02).
CONCLUSION
As these cells are pivotal in Anti-tumor and anti-infectious immunity, it would be greatly interesting to modulate with the Bio-Stim® device the activity of these cells in subjects with cancer, for example, in order to enhance their natural immunity.
R. Mandeville, M.D., Ph.D., Biophage Inc., Montreal, P.Q.
Three (3) subjects aged 25 to 40 years with no disease or malfunction of the immune system were exposed to PEMF for 28 consecutive days, at 15 minutes per day.
The immune system parameters studied were:
1) Total white blood cell count
2) Immunophenotyping
3) Evaluation of NK (Natural Killer) cell activity.
Technically, the BIO-STIM® System was used with the pair of rings as applicator spaced 30 cm apart (one ring under the buttocks and one ring at breast level). The Generator was programmed with the following parameters: A6, F60, M2, T15. The field intensity was 125 milli Gauss or 12.5 μ Tesla. Statistically, Student's T-test validated the results with a confidence limit of P<0.05.
Result: PEMF does not affect the distribution of the various lymphocyte populations studied from peripheral blood, namely, total white blood cells and total lymphocytes. However, B lymphocytes experienced a slight upward trend during the second week of treatment. Regarding T lymphocyte subpopulations, no major changes were detected. The CD8/CD4 ratio remained stable throughout the treatment period and persisted four (4) weeks after the end of treatments.
As for NK cells isolated from peripheral blood, a very significant increase in their activity is observed and persists until the end of the treatment, which lasted four (4) weeks. It should also be noted that a return to normal is observed four (4) weeks after the end of all PEMF treatments.
Although the number of subjects was limited, it is worth noting the significant and reversible increase in NK cell activity, thus promoting the natural immunity of the individual and B cells. Furthermore, the stable CD8/CD4 ratio throughout the treatment period is important for maintaining the homeostasis of both humoral and cellular immune systems. A stable CD8/CD4 ratio supports the safety of PEMF treatment.
A more in-depth study could confirm that exposure to PEMF from the BIO-STIM® System acts as a modulator of certain components of the immune system. With the preservation of cellular populations' homeostasis throughout the study, treatment with the BIO-STIM® System appears to be part of the mild line of immunomodulators that stimulate certain types of cells without acting to the detriment of immune system balance.
CONCLUSION
As these cells are pivotal in Anti-tumor and anti-infectious immunity, it would be greatly interesting to modulate with the Bio-Stim® device the activity of these cells in subjects with cancer, for example, in order to enhance their natural immunity.
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